Detailed view for Bm1_42025

Basic information

TDR Targets ID: 241487
Brugia malayi, Protein-tyrosine phosphatase
Source Database / ID:  GenBank

pI: 6.9918 | Length (AA): 1528 | MW (Da): 172236 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain
PF00102   Protein-tyrosine phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0005515   protein binding  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
102 340 1fnf (A) 1265 1483 31.00 0.000085 1 0.293714 1.03
274 354 4lpu (A) 4 82 32.00 0 1 0.52591 -1.09
697 808 1x5l (A) 26 110 46.00 0.013 0.49 0.228598 0.34
1042 1424 2b3o (A) 105 519 27.00 0 1 0.551554 -0.01
1132 1424 3s3e (A) 20 305 55.00 0.00000000028 1 0.868654 -0.98
1134 1527 2fh7 (A) 1369 1755 31.00 0.00000000057 1 0.585753 0.01
1138 1427 2nz6 (A) 1021 1309 46.00 0 1 0.779091 -1.09
1145 1419 1rpm (A) 887 1153 42.00 0.00000038 1 0.719874 -0.91
1159 1527 2jjd (A) 136 501 38.00 0.0000000054 1 0.570392 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132503)

Species Accession Gene Product
Brugia malayi Bm1_42025   Protein-tyrosine phosphatase
Candida albicans CaO19.13722   phosphotyrosine-specific protein phosphatase
Candida albicans CaO19.6365   phosphotyrosine-specific protein phosphatase
Caenorhabditis elegans CELE_F44G4.8   Protein DEP-1, isoform B
Drosophila melanogaster Dmel_CG1817   Protein tyrosine phosphatase 10D
Drosophila melanogaster Dmel_CG6899   Protein tyrosine phosphatase 4E
Homo sapiens ENSG00000127329   protein tyrosine phosphatase, receptor type, B
Loa Loa (eye worm) LOAG_03887   hypothetical protein
Loa Loa (eye worm) LOAG_12391   hypothetical protein
Loa Loa (eye worm) LOAG_10550   hypothetical protein
Loa Loa (eye worm) LOAG_15592   hypothetical protein
Mus musculus ENSMUSG00000020154   protein tyrosine phosphatase, receptor type, B
Onchocerca volvulus OVOC10784  
Schistosoma japonicum Sjp_0127660   ko:K05694 protein tyrosine phosphatase, receptor type, B, putative
Schmidtea mediterranea mk4.003151.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein tyrosine phosphatase, receptor type, B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0216 0.706 1
0.0343 0.706 1
0.0962 0.3272 0.7536
0.0083 1 1
0.0461 0.2819 0.999
0.0351 0.6072 1
0.0178 0.5983 0.5
0.0011 1 0.5
0.2164 0.2967 0.2967
0.0608 0.3272 0.5832
0.0223 0.4639 0
0.0446 0.3014 0.2972
0.0103 0.6765 0.6765
0.0085 0.3268 0.4093
0.0039 0.3299 0.4024
0.0461 0.2819 0.999
0.0103 0.387 0.387
0.0084 0.6788 1
0.0103 0.8143 0.8137
0.0587 0.6957 0.6672
0.028 0.3452 0.5791
0.0142 0.2992 0.3965
0.0111 0.334 0.3848
0.0241 0.3986 0.5216
0.0352 0.6704 1
0.0258 0.3891 0.5117
0.0391 0.4012 0.3396
0.0266 0.2855 1
0.0084 0.6788 1
0.0167 0.3197 0.4301
0.0153 0.3082 0.4077
0.0165 0.3513 0.4712
0.0184 0.706 1
0.0414 0.6115 1
0.019 0.4711 0.4416
0.0114 0.6153 1
0.0338 0.7566 1
0.0374 0.7576 1
0.0261 0.3873 0.5021
0.0366 0.299 0.299
0.022 0.257 0.5218
0.0272 0.706 1
0.0156 0.6042 1
0.0943 0.736 0.6687
0.048 0.5259 0.4785
0.0255 0.706 1
0.0943 0.736 0.6687
0.0251 0.7407 1
0.0115 0.2557 0.3611
0.0378 0.586 1
0.0275 0.301 0.4695
0.0378 0.586 1
0.0132 0.2972 0.4456
0.0461 0.2819 0.999
0.0034 0.2581 0.2581
0.0129 0.3276 0.8182
0.0204 0.279 0.2788
0.0048 0.4176 0.4167
0.0288 0.9096 0
0.0261 0.2557 0.3611
0.0009 0.5 0.5
0.0461 0.2819 0.999
0.0446 0.3014 0.2972
0.0275 0.301 0.4695
0.0156 0.6042 1
0.0471 0.341 1
0.037 0.706 1
0.019 0.4711 0.4416
0.075 0.5364 0.4687
0.0359 0.4784 1
0.0334 0.4633 0.6876
0.019 0.4711 0.4416
0.0275 0.301 0.4695
0.0223 0.4639 0
0.043 0.5151 1
0.0488 0.3798 1
0.022 0.257 0.5218
0.0354 0.5734 1
0.0275 0.301 0.4695
0.0446 0.3014 0.2972
0.0011 1 1
0.0354 0.5734 1
0.0312 0.5397 1
0.0475 0.706 1
0.2164 0.2967 0.2967
0.0271 0.3613 1
0.0714 0.2584 0.5056
0.0075 0.4317 0.4742
0.0446 0.3014 0.2972
0.0374 0.7576 1
0.0446 0.3014 0.2972
0.0275 0.301 0.4695
0.0366 0.299 0.299
0.0255 0.2557 0.3611
0.0564 0.5136 1
0.0178 0.5983 0.5
0.0446 0.3014 0.2972
0.0354 0.5734 1
0.0334 0.4633 0.6876
0.0366 0.299 0.299
0.0343 0.706 1
0.0372 0.6327 0
0.0414 0.6115 1
0.0048 0.432 0.432
0.0344 0.6972 0.8423
0.0446 0.3014 0.2972
0.012 0.7362 0.9962
0.0251 0.7407 1
0.0164 0.7647 0.7789
0.0448 0.7636 1
0.026 0.6503 1
0.0104 0.8804 0.8804
0.0089 0.442 0.3902
0.0241 0.3619 0.4827
0.0286 0.3222 0.4833
0.0336 0.3462 1
0.0272 0.5774 0.5774
0.0878 0.6022 1
0.0216 0.3372 0.4556
0.0116 0.6967 0.9164
0.0016 1 1
0.012 0.7362 0.9962
0.0167 0.3197 0.4301
0.0103 0.6765 0.6765
0.0471 0.341 1
0.0089 0.4623 0.4623
0.017 0.2614 1
0.0313 0.5953 1
0.0701 0.3108 0.5551
0.0155 0.3568 1
0.0263 0.3866 1
0.0255 0.706 1
0.008 0.4641 0
0.0165 0.3513 0.4712
0.0446 0.3014 0.2972
0.02 0.7068 1
0.0564 0.5136 1
0.0403 0.706 1
0.0564 0.5136 1
0.0011 1 0.5
0.0089 0.442 0.3902

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_42025 (Brugia malayi), Protein-tyrosine phosphatase
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